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Article

The genetic evolution of acral melanoma.

Nature communications - 21 Jul 2024

Wang Meng, Fukushima Satoshi, Sheen Yi-Shuan, Ramelyte Egle, Cruz-Pacheco Noel, Shi Chenxu, Liu Shanshan, Banik Ishani, Aquino Jamie D, Sangueza Acosta Martin, Levesque Mitchell, Dummer Reinhard, Liau Jau-Yu, Chu Chia-Yu, Shain A Hunter, Yeh Iwei, Bastian Boris C

Abstract excerpt

Acral melanoma is an aggressive type of melanoma with unknown origins. It is the most common type of melanoma in individuals with dark skin and is notoriously challenging to treat. We examine exome sequencing data of 139 tissue samples, spanning different progression stages, from 37 patients. We find that 78.4% of the melanomas display clustered copy number transitions with focal amplifications, recurring...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39034322
DOI: 10.1038/s41467-024-50233-z
PMCID: PMC11271482

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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