Article
Genomic characterization reveals distinct mutational landscape of acral melanoma in East Asian.
Journal of genetics and genomics = Yi chuan xue bao - 1 Apr 2025
Zhang Fenghao, Wu Xiaowen, Jiao Tao, Du Haizhen, Guo Qian, Cui Chuanliang, Chi Zhihong, Sheng Xinan, Jiang Dezhi, Zhang Yuhong, Wu Jiayan, Kong Yan, Si Lu
Abstract excerpt
Acral melanoma, the most common melanoma subtype in East Asia, is associated with a poor prognosis. This study aims to comprehensively analyze the genomic characteristics of acral melanoma in East Asians. We conduct whole-genome sequencing of 55 acral melanoma tumors and perform data mining with relevant clinical data. Our findings reveal a unique mutational profile in East Asian acral melanoma, characterized by...
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