Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma.

doi:10.1101/gr.213348.116

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Article

Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma.

Genome research - 1 Apr 2017

Liang Winnie S, Hendricks William, Kiefer Jeffrey, Schmidt Jessica, Sekar Shobana, Carpten John, Craig David W, Adkins Jonathan, Cuyugan Lori, Manojlovic Zarko, Halperin Rebecca F, Helland Adrienne, Nasser Sara, Legendre Christophe, Hurley Laurence H, Sivaprakasam Karthigayini, Johnson Douglas B, Crandall Holly, Busam Klaus J, Zismann Victoria, Deluca Valerie, Lee Jeeyun, Sekulic Aleksandar, Ariyan Charlotte E, Sosman Jeffrey, Trent Jeffrey

Abstract excerpt

Genomic analyses of cutaneous melanoma (CM) have yielded biological and therapeutic insights, but understanding of non-ultraviolet (UV)-derived CMs remains limited. Deeper analysis of acral lentiginous melanoma (ALM), a rare sun-shielded melanoma subtype associated with worse survival than CM, is needed to delineate non-UV oncogenic mechanisms. We thus performed comprehensive genomic and transcriptomic analysis...

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Identifiers

PMID: 28373299
DOI: 10.1101/gr.213348.116
PMCID: PMC5378171

Genes

TERT
BRAF
NRAS
PAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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