Article
Whole-genome landscapes of major melanoma subtypes.
Nature - 11 May 2017
Hayward Nicholas K, Wilmott James S, Waddell Nicola, Johansson Peter A, Field Matthew A, Nones Katia, Patch Ann-Marie, Kakavand Hojabr, Alexandrov Ludmil B, Burke Hazel, Jakrot Valerie, Kazakoff Stephen, Holmes Oliver, Leonard Conrad, Sabarinathan Radhakrishnan, Mularoni Loris, Wood Scott, Xu Qinying, Waddell Nick, Tembe Varsha, Pupo Gulietta M, De Paoli-Iseppi Ricardo, Vilain Ricardo E, Shang Ping, Lau Loretta M S, Dagg Rebecca A, Schramm Sarah-Jane, Pritchard Antonia, Dutton-Regester Ken, Newell Felicity, Fitzgerald Anna, Shang Catherine A, Grimmond Sean M, Pickett Hilda A, Yang Jean Y, Stretch Jonathan R, Behren Andreas, Kefford Richard F, Hersey Peter, Long Georgina V, Cebon Jonathan, Shackleton Mark, Spillane Andrew J, Saw Robyn P M, López-Bigas Núria, Pearson John V, Thompson John F, Scolyer Richard A, Mann Graham J
Abstract excerpt
Melanoma of the skin is a common cancer only in Europeans, whereas it arises in internal body surfaces (mucosal sites) and on the hands and feet (acral sites) in people throughout the world. Here we report analysis of whole-genome sequences from cutaneous, acral and mucosal subtypes of melanoma. The heavily mutated landscape of coding and non-coding mutations in cutaneous melanoma resolved novel signatures of...
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