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Article

Comprehensive Genomic Profiling of Acral Melanoma: Insights From the AACR Project GENIE Database.

The American Journal of dermatopathology - 1 May 2026

Russolillo Julia K, Schaedler Alex, Hsia Beau, Silberstein Peter T, Tauseef Abubakar, Torbenson Elijah

Abstract excerpt

BACKGROUND: Acral melanoma (AM) is a rare but aggressive melanoma subtype that arises on palmoplantar surfaces and nail units. It disproportionately affects individuals with darker skin tones and is frequently diagnosed at advanced stages. Limited genomic data have hindered the development of effective targeted therapies. METHODS: A retrospective genomic analysis of AM was conducted using the American Association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41650285
DOI: 10.1097/DAD.0000000000003237
PMCID: PMC13095056

Genes

TERT
BRAF
CCND1
CDK4
CDKN2A
CDKN2B
KIT
KRAS
NAB2
NF1
NRAS
PTPRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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