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Article

Affective dysfunction in a mouse model of Rett syndrome: Therapeutic effects of environmental stimulation and physical activity.

Developmental neurobiology - 1 Feb 2016

Kondo Mari A, Gray Laura J, Pelka Gregory J, Leang Sook-Kwan, Christodoulou John, Tam Patrick P L, Hannan Anthony J

Abstract excerpt

Rett syndrome (RTT) is a neurodevelopmental disorder associated with mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2) and consequent dysregulation of brain maturation. Patients suffer from a range of debilitating physical symptoms, however, behavioral and emotional symptoms also severely affect their quality of life. Here, we present previously unreported and clinically relevant...

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Identifiers

PMID: 26019053
DOI: 10.1002/dneu.22308

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BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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