Article
Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome.
Human molecular genetics - 1 Aug 2016
Veeraragavan Surabi, Wan Ying-Wooi, Connolly Daniel R, Hamilton Shannon M, Ward Christopher S, Soriano Sirena, Pitcher Meagan R, McGraw Christopher M, Huang Sharon G, Green Jennie R, Yuva Lisa A, Liang Agnes J, Neul Jeffrey L, Yasui Dag H, LaSalle Janine M, Liu Zhandong, Paylor Richard, Samaco Rodney C
Abstract excerpt
Mouse models of the transcriptional modulator Methyl-CpG-Binding Protein 2 (MeCP2) have advanced our understanding of Rett syndrome (RTT). RTT is a 'prototypical' neurodevelopmental disorder with many clinical features overlapping with other intellectual and developmental disabilities (IDD). Therapeutic interventions for RTT may therefore have broader applications. However, the reliance on the laboratory mouse to...
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