The Exposure to a Neuronal Plasticity-Dependent Paradigm and Young-Plasma Treatment Decreases the Progression of Rett Syndrome-Like Phenotype by Preventing Synaptic and Motor Deficit

Abstract excerpt

Classical Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the MECP2 gene, resulting in a devastating phenotype associated with a lack of gene expression control. Mouse models lacking Mecp2 expression with an RTT-like phenotype have been developed to advance therapeutic alternatives. Environmental enrichment (EE) attenuates RTT symptoms in patients and mouse models. However, the mechanis...

Topics

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• Behavior, Animal
• Brain-Derived Neurotrophic Factor
• Cognition Disorders
• Maze Learning
• Methyl-CpG-Binding Protein 2
• Mice, Mutant Strains
• Rett Syndrome
• Synapses

Identifiers and source

Literature Corpus work

36ec36c9-af2a-51c0-942a-aef07383380f

DOI

10.20944/preprints202412.1517.v1