Article
Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome.
The Journal of comparative neurology - 1 May 2008
Belichenko Nadia P, Belichenko Pavel V, Li Hong Hua, Mobley William C, Francke Uta
Abstract excerpt
Rett syndrome (RTT) is caused by mutations in the X-linked gene MECP2. While patients with RTT show widespread changes in brain function, relatively few studies document changes in brain structure and none examine in detail whether mutations causing more severe clinical phenotypes are linked to more marked changes in brain structure. To study the influence of MeCP2-deficiency on the morphology of brain areas and...
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