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Precision DNA Impurity Reduction Approaches for Ultra-Pure rAAV Manufacturing

2026-04-07

Abstract excerpt

Recombinant adeno-associated virus (rAAV) vectors are a leading platform for gene delivery in basic and clinical research, yet large-scale manufacturing remains constrained by residual nucleic-acid impurities that compromise safety. In this study, we profiled the DNA species packaged within rAAV capsids and identified plasmid backbone sequences and host cell genomic DNA (hcDNA) as predominant contaminants. To miti...

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Literature Corpus work
281c8b63-d101-5d69-9de5-aa62eab74ae7
DOI
10.64898/2026.04.07.716878
Open publication

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Precision DNA Impurity Reduction Approaches for Ultra-Pure rAAV ManufacturingDOI 10.64898/2026.04.07.716878
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