Article

Characterizing the Biopotency of Truncated Transgene Variants in rAAV8 viral vectors: Essential Considerations for Gene Therapy Applications

2024-04-04

Abstract excerpt

<title>Abstract</title> <p>Background The production of recombinant Adeno-Associated Virus (rAAV) vectors for gene therapy applications is a critical process, especially when dealing with large transgenes that challenge the 4.7kb capacity limit of rAAV. We aimed to investigate the variances in recombinant rAAV samples post-ultracentrifugation produced in HEK293, focusing on those rAAV8s with either single-strand...

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Literature Corpus work: 5b3057c8-b8af-5b21-946a-1f01721d581e
DOI: 10.21203/rs.3.rs-4043201/v1

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