Article

Removal of Empty Capsids from High-Dose Adeno-Associated Virus 9 Gene Therapies

2024-04-14

Abstract excerpt

Recombinant adeno-associated virus, serotype 9 (rAAV9) has shown promise as a gene therapy vector for muscle and central nervous diseases. High-dose requirements of these therapies present critical safety considerations and biomanufacturing challenges. Notably, reduction of empty capsids (ECs), which lack therapeutic transgene, from rAAV9 products is critical to maximize efficacy. Removal of rAAV ECs from full cap...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 535695c3-85e1-50ee-8298-b9ee37cd366c
DOI: 10.22541/au.171311478.84577099/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Removal of Empty Capsids from High-Dose Adeno-Associated Virus 9 Gene TherapiesDOI 10.22541/au.171311478.84577099/v1Read

Analytical Strategies for Quantification of Adeno-Associated Virus Empty Capsids to Support Process DevelopmentSemantic proximity Read

Anion-Exchange Chromatography at the Service of Gene Therapy: Baseline Separation of Full/Empty Adeno-Associated Virus Capsids by Screening of Conditions and Step Gradient Elution ModeSemantic proximity Read

Critical challenges and advances in recombinant adeno‐associated virus (rAAV) biomanufacturingSemantic proximity Read

Anion-exchange HPLC assay for separation and quantification of empty and full capsids in multiple adeno-associated virus serotypesSemantic proximity Read

Tuning Mobile Phase Properties to Improve Empty Full Particle Separation in Adeno-associated Virus by Anion Exchange ChromatographySemantic proximity Read

Analytical methods for process and product characterization of recombinant adeno-associated virus-based gene therapiesSemantic proximity Read

Manufacturing of recombinant adeno-associated viral vectors for clinical trialsSemantic proximity Read

Viral vector manufacturing: how to address current and future demands?Semantic proximity Read

A scalable method for the production of high-titer and high-quality adeno-associated type 9 vectors using the HSV platformSemantic proximity Read

Significant Differences in Capsid Properties and Potency Between Adeno-Associated Virus Vectors Produced in Sf9 and HEK293 CellsSemantic proximity Read

Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV ManufacturingSemantic proximity Read

Virus Filtration Development for Adeno‐Associated Virus‐Based Gene Therapy ProductsSemantic proximity Read