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Critical challenges and advances in recombinant adeno‐associated virus (rAAV) biomanufacturing

1 May 2023

Abstract excerpt

Gene therapy is a promising therapeutic approach for genetic and acquired diseases nowadays. Among DNA delivery vectors, recombinant adeno-associated virus (rAAV) is one of the most effective and safest vectors used in commercial drugs and clinical trials. However, the current yield of rAAV biomanufacturing lags behind the necessary dosages for clinical and commercial use, which embodies a concentrated reflection...

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PMID: 37126355
DOI: 10.1002/bit.28412

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