Article

The Mitochondrial Permeability Transition Pore Activates the Mitochondrial Unfolded Protein Response and Promotes Aging

2020-11-04

Abstract excerpt

<h4>SUMMARY</h4> Mitochondrial activity determines aging rate and the onset of chronic diseases. The mitochondrial permeability transition pore (mPTP) is a pathological pore in the inner mitochondrial membrane thought to be composed of the F-ATP synthase (complex V). OSCP, a subunit of F-ATP synthase, helps protect against mPTP formation. How the destabilization of OSCP may contribute to aging, however, is unclea...

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Literature Corpus work: 2812d23b-8c20-5382-b658-326a118f2c1a
DOI: 10.1101/2020.11.03.366815

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