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Article

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing.

Nature reviews. Molecular cell biology - 1 Feb 2018

Shpilka Tomer, Haynes Cole M

Abstract excerpt

Mitochondrial function declines during ageing owing to the accumulation of deleterious mitochondrial genomes and damage resulting from the localized generation of reactive oxygen species, both of which are often exacerbated in diseases such as Parkinson disease. Cells have several mechanisms to assess mitochondrial function and activate a transcriptional response known as the mitochondrial unfolded protein...

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Identifiers

PMID: 29165426
DOI: 10.1038/nrm.2017.110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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