Article
Tau proteinopathies and the prion concept.
Progress in molecular biology and translational science - 1 Jan 2020
Goedert Michel
Abstract excerpt
The ordered assembly of a small number of proteins into amyloid filaments is central to age-related neurodegenerative diseases. Tau is the most commonly affected of these proteins. In sporadic diseases, assemblies of tau form in a stochastic manner in certain brain regions, from where they appear to spread in a deterministic way, giving rise to disease symptoms. Over the past decade, multiple lines of evidence...
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