Article

LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons

2024-06-08

Abstract excerpt

Haloperidol is used to manage psychotic symptoms in several neurological disorders through mechanisms that involve antagonism of dopamine D2 receptors that are highly expressed in the striatum. Significant side effects of haloperidol, known as extrapyramidal symptoms, lead to motor deficits similar to those seen in Parkinson’s disease and present a major challenge in clinical settings. The underlying molecular mec...

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Literature Corpus work: 27eca4ba-8946-5622-addd-3757124dbcd3
DOI: 10.1101/2024.06.06.597594

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