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Article

Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications.

Movement disorders : official journal of the Movement Disorder Society - 1 Jul 2011

Yue Zhenyu, Lachenmayer M Lenard

Abstract excerpt

Dominantly inherited mutations in leucine-rich repeat kinase 2 are the most common cause of familial Parkinson's disease. Understanding leucine-rich repeat kinase 2 biology and pathophysiology is central to the elucidation of Parkinson's disease etiology and development of disease intervention. Recently, a number of genetic mouse models of leucine-rich repeat kinase 2 have been reported utilizing different...

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Identifiers

PMID: 21538530
DOI: 10.1002/mds.23737
PMCID: PMC3150637

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Source receipt: pubmed, retrieved 7 Sept 2026.

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