Article
R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations.
Communications biology - 10 Nov 2022
Xenias Harry S, Chen Chuyu, Kang Shuo, Cherian Suraj, Situ Xiaolei, Shanmugasundaram Bharanidharan, Liu Guoxiang, Scesa Giuseppe, Chan C Savio, Parisiadou Loukia
Abstract excerpt
LRRK2 mutations are closely associated with Parkinson's disease (PD). Convergent evidence suggests that LRRK2 regulates striatal function. Here, by using knock-in mouse lines expressing the two most common LRRK2 pathogenic mutations-G2019S and R1441C-we investigated how LRRK2 mutations altered striatal physiology. While we found that both R1441C and G2019S mice displayed reduced nigrostriatal dopamine release,...
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