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Article

The LRRK2 signalling system.

Cell and tissue research - 1 Jul 2018

Price Alice, Manzoni Claudia, Cookson Mark R, Lewis Patrick A

Abstract excerpt

The LRRK2 gene is a major contributor to genetic risk for Parkinson's disease and understanding the biology of the leucine-rich repeat kinase 2 (LRRK2, the protein product of this gene) is an important goal in Parkinson's research. LRRK2 is a multi-domain, multi-activity enzyme and has been implicated in a wide range of signalling events within the cell. Because of the complexities of the signal transduction...

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Identifiers

PMID: 29308544
DOI: 10.1007/s00441-017-2759-9
PMCID: PMC6015615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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