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Recent Developments in LRRK2-Targeted Therapy for Parkinson's Disease.

Drugs - 1 Jul 2019

Zhao Ye, Dzamko Nicolas

Abstract excerpt

Kinase activating missense mutations in leucine-rich repeat kinase 2 (LRRK2) are pathogenically linked to neurodegenerative Parkinson's disease (PD). Over the past decade, substantial effort has been devoted to the development of potent and selective small molecule inhibitors of LRRK2, as well as their preclinical testing across different Parkinson's disease models. This review outlines the genetic and...

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PMID: 31161537
DOI: 10.1007/s40265-019-01139-4

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