Article

Variability in mitochondrial import, mitochondrial health and mtDNA copy number using Type II and Type V CRISPR effectors

2020-03-11

Abstract excerpt

<h4>ABSTRACT</h4> Current methodologies for targeting the mitochondrial genome for basic research and/or therapeutic strategy development in mitochondrial diseases are restricted by practical limitations and technical inflexibility. The development of a functional molecular toolbox for CRISPR-mediated mitochondrial genome editing is therefore desirable, as this could enable precise targeting of mtDNA haplotypes u...

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Literature Corpus work: 278da96b-7b8c-551c-9bba-a4bf9d222726
DOI: 10.1101/2020.03.10.985606

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