Article
Development of mitochondrial gene-editing strategies and their potential applications in mitochondrial hereditary diseases: a review.
Cytotherapy - 1 Jan 2024
Gao Yanyan, Guo Linlin, Wang Fei, Wang Yin, Li Peifeng, Zhang Dejiu
Abstract excerpt
Mitochondrial DNA (mtDNA) is a critical genome contained within the mitochondria of eukaryotic cells, with many copies present in each mitochondrion. Mutations in mtDNA often are inherited and can lead to severe health problems, including various inherited diseases and premature aging. The lack of efficient repair mechanisms and the susceptibility of mtDNA to damage exacerbate the threat to human health....
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