Article

Targeting of human mitochondrial DNA with programmable pAgo nuclease

2025-11-21

Abstract excerpt

Manipulating the mitochondrial genome remains a major challenge in genetic engineering, largely due to the mitochondrial double-membrane structure. While recent advances have expanded the genetic toolkit for nuclear and cytoplasmic targets, precise editing of mtDNA has remained elusive. Here we report the first successful mitochondrial import of a functional RNA-guided prokaryotic Argonaute protein from the mesoph...

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Literature Corpus work: 3d60a184-9945-57e8-970c-978b07d200a4
DOI: 10.1101/2025.11.20.689640

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