Article

Mitochondrial genome microhomology-mediated editing by donor DNA delivery into mitochondria in human cells

2025-11-02

Abstract excerpt

<h4>Summary</h4> Mutations in the mitochondrial DNA (mtDNA) are associated with severe human diseases, lacking efficient therapies. Direct correction of mtDNA mutations may offer a cure for such diseases. We propose a novel strategy based on double-stranded DNA (dsDNA) oligonucleotide delivery into mitochondria and intrinsic microhomology-mediated end joining (MMEJ) for mtDNA editing. This strategy enables introd...

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Literature Corpus work: 8819543f-558e-54a6-a8c5-ab0053b9c5bc
DOI: 10.1101/2025.11.02.686110

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