Article
In vivo imaging of mitochondrial DNA mutations using an integrated nano Cas12a sensor.
Nature communications - 24 Nov 2023
Li Yanan, Wu Yonghua, Xu Ru, Guo Jialing, Quan Fenglei, Zhang Yongyuan, Huang Di, Pei Yiran, Gao Hua, Liu Wei, Liu Junjie, Zhang Zhenzhong, Deng Ruijie, Shi Jinjin, Zhang Kaixiang
Abstract excerpt
Mutations in mitochondrial DNA (mtDNA) play critical roles in many human diseases. In vivo visualization of cells bearing mtDNA mutations is important for resolving the complexity of these diseases, which remains challenging. Here we develop an integrated nano Cas12a sensor (InCasor) and show its utility for efficient imaging of mtDNA mutations in live cells and tumor-bearing mouse models. We co-deliver...
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