The evolutionary history of 2,658 cancers.

doi:10.1038/s41586-019-1907-7

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Article

The evolutionary history of 2,658 cancers.

Nature - 1 Feb 2020

Gerstung Moritz, Jolly Clemency, Leshchiner Ignaty, Dentro Stefan C, Gonzalez Santiago, Rosebrock Daniel, Mitchell Thomas J, Rubanova Yulia, Anur Pavana, Yu Kaixian, Tarabichi Maxime, Deshwar Amit, Wintersinger Jeff, Kleinheinz Kortine, Vázquez-García Ignacio, Haase Kerstin, Jerman Lara, Sengupta Subhajit, Macintyre Geoff, Malikic Salem, Donmez Nilgun, Livitz Dimitri G, Cmero Marek, Demeulemeester Jonas, Schumacher Steven, Fan Yu, Yao Xiaotong, Lee Juhee, Schlesner Matthias, Boutros Paul C, Bowtell David D, Zhu Hongtu, Getz Gad, Imielinski Marcin, Beroukhim Rameen, Sahinalp S Cenk, Ji Yuan, Peifer Martin, Markowetz Florian, Mustonen Ville, Yuan Ke, Wang Wenyi, Morris Quaid D, Spellman Paul T, Wedge David C, Van Loo Peter

Abstract excerpt

Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes3. Here, by whole-genome sequencing analysis of 2,658 cancers as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome...

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Identifiers

PMID: 32025013
DOI: 10.1038/s41586-019-1907-7
PMCID: PMC7054212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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