Article
The ASPP family: deciding between life and death after DNA damage.
Toxicology letters - 4 Apr 2003
Slee Elizabeth A, Lu Xin
Abstract excerpt
It is well established that p53 is a primary target for mutation in human cancer. p53 carries out the important task of ensuring that damaged DNA is not passed on during cell division, a duty that it performs by either inhibiting the cell cycle or inducing apoptosis. However, it is unclear how this decision is made. The recent identification of the ASPP family of proteins, which act to direct the cell away from...
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