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Article

Functional interplay between p53 and Δ133p53 in adaptive stress response.

Cell death and differentiation - 1 May 2020

Gong Lu, Pan Xiao, Abali Gamze K, Little John B, Yuan Zhi-Min

Abstract excerpt

Apart from its well-known prodeath activity, p53 is also implicated in promoting cell survival. How p53 can mediate such seemingly opposing effects is largely unclear. We report here a novel mechanism in which p53-mediated proapoptosis is switched to antiapoptosis via its interaction with a p53 isoform, Δ133p53. We show that the expression of Δ133p53 is induced by mild or a moderate level of stress via an...

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Identifiers

PMID: 31659281
DOI: 10.1038/s41418-019-0445-z
PMCID: PMC7206045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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