Article
Tumour suppression by p53: the importance of apoptosis and cellular senescence.
The Journal of pathology - 1 Sept 2009
Zuckerman Valentina, Wolyniec Kamil, Sionov Ronit V, Haupt Sue, Haupt Ygal
Abstract excerpt
p53 is regarded as a central player in tumour suppression, as it controls programmed cell death (apoptosis) as well as cellular senescence. While apoptosis eliminates cells at high risk for oncogenic transformation, senescence acts as a barrier to tumourigenesis by imposing irreversible cell cycle arrest. p53 can act directly or indirectly at multiple levels of the tumour suppression network by invoking a myriad...
Topics
- Apoptosis
- Cellular Senescence
- DNA-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Genetic Therapy
- Humans
- MicroRNAs
- Mutation
- Neoplasms
- Nuclear Proteins
- Protein Isoforms