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Article

Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis

15 Apr 2021

Abstract excerpt

Abstract Escape from programmed cell death is a hallmark of cancer. In this study, we investigated the anti-apoptotic mechanisms and explored the therapeutic potential of BCL-2 homology domain-3 (BH3) mimetics in malignant pleural mesothelioma (MPM), a lethal thoracic malignancy with an extreme dearth of treatment options. By implementing integrated analysis of functional genomic data of MPM cells and...

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PMID: 33859162
DOI: 10.1038/s41419-021-03668-x

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