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Article

Rap2b, a novel p53 target, regulates p53-mediated pro-survival function

12 Apr 2013

Abstract excerpt

The tumor suppressor p53 is a critical regulator of apoptosis and cell cycle arrest/pro-survival. Upon DNA damage, p53 evokes both cell cycle arrest/pro-survival and apoptosis transcriptional programs. The ultimate cellular outcome depends on the balance of these two programs. However, the p53 downstream targets that mediate this cell fate decision remain to be identified. Using an integrative genomic approach,...

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PMID: 23535297
DOI: 10.4161/cc.24364

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