Article

The cell death machinery governed by the p53 tumor suppressor in response to DNA damage

2009-12-28

Abstract excerpt

The cellular response to genotoxic stress that damages DNA includes cell cycle arrest, activation of DNA repair, and in the event of irreparable damage, induction of apoptosis. However, the signals that determine cell fate, that is, survival or apoptosis, are largely unclear. The tumor suppressor p53 has been implicated in many important cellular processes, including regulation of apoptotic cell death. When cells...

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Identifiers and source

Literature Corpus work: d6973841-986c-5c88-9219-7f1c7f40c713
DOI: 10.1111/j.1349-7006.2009.01488.x

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