Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Life and Death Decision-Making by p53 and Implications for Cancer Immunotherapy.

Trends in cancer - 1 Mar 2021

Liu Yong, Leslie Patrick L, Zhang Yanping

Abstract excerpt

The tumor-suppressor protein p53 is mutated in approximately half of all cancers, whereas the p53 signaling network is perturbed in almost all cancers. In response to different stress stimuli, p53 selectively activates genes to elicit a cell survival or cell death response. How p53 makes the decision between life and death remains a fascinating question and an exciting field of research. Understanding how this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Neoplasm
Share to Cell Survival
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune Checkpoint Inhibitors

Share to Immunotherapy, Adoptive

Share to MicroRNAs

Share to Protein Processing, Post-Translational

Share to Receptors, Chimeric Antigen

Source

Open in PubMed Open full text

Identifiers

PMID: 33199193
DOI: 10.1016/j.trecan.2020.10.005
PMCID: PMC7889652

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Life and Death Decision-Making by p53 and Implications for Cancer Immunotherapy.PMID 33199193Read ↗

Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy.Semantic proximity Read ↗

Controlling the unfolded protein response-mediated life and death decisions in cancerSemantic proximity Read ↗

p53 at the crossroads of tumor immunity.Semantic proximity Read ↗

A Different Facet of p53 Function: Regulation of Immunity and Inflammation During Tumor DevelopmentSemantic proximity Read ↗

p53, cancer and the immune response.Semantic proximity Read ↗

The guardian of the genome meets immunotherapy: p53-based strategies.Semantic proximity Read ↗

Potential role of p53 deregulation in modulating immune responses in human malignancies: A paradigm to develop immunotherapy.Semantic proximity Read ↗

P53 and The Immune Response: 40 Years of Exploration—A Plan for the FutureSemantic proximity Read ↗

The Wheel of p53 Helps to Drive the Immune SystemSemantic proximity Read ↗

Regulation of tissue‐ and stimulus‐specific cell fate decisions by <i>p53 in vivo</i>Semantic proximity Read ↗

Life and death by p53.Semantic proximity Read ↗

To die or not to die: how does p53 decide?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.