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Article

Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2006

Aprahamian Tamar, Bonegio Ramon, Rizzo Jennifer, Perlman Harris, Lefer David J, Rifkin Ian R, Walsh Kenneth

Abstract excerpt

Patients with systemic lupus erythematosus develop accelerated atherosclerosis independent of traditional risk factors. The 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors are widely prescribed for hyperlipidemia, but they also exhibit anti-inflammatory actions that appear to be independent of their suppressive actions on plasma cholesterol levels. In this study, we analyzed the effect of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16920939
DOI: 10.4049/jimmunol.177.5.3028
PMCID: PMC2752011

Genes

STAT4
STAT6
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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