Article

Omega-3 Fatty Acid Synergy with Glucocorticoid in Lupus Macrophages: Targeting Pathogenic Pathways to Reduce Steroid Dependence

2025-06-17

Abstract excerpt

<h4>Introduction</h4> Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by aberrant inflammation, type I IFN-stimulated gene (ISG) expression, and autoantibody production. Glucocorticoids (GCs) like dexamethasone (DEX) are standard long-term SLE treatments but cause significant side effects, highlighting the need for safer steroid-sparing options. Preclinical and clinical studies s...

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Literature Corpus work: 77d9d1fd-5a60-5f1e-b101-205ab7182c97
DOI: 10.1101/2025.06.12.658906

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