Article

Discovery of post-translationally modified self-peptides that promote hypertension

2023-07-19

Abstract excerpt

Post translational modifications can enhance immunogenicity of self-proteins. In several conditions including hypertension, systemic lupus, and heart failure, isolevuglandins (IsoLGs) are formed by lipid peroxidation and covalently bond with protein lysine residues. Here we show that the murine class-I major histocompatibility complex (MHC-I) variant H-2D b uniquely presents isoLG modified peptides and developed...

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Literature Corpus work: 22830233-2c4b-5ca2-9d65-dcabbfc6aa22
DOI: 10.1101/2023.07.18.549523

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