Article

The aconitate decarboxylase 1/itaconate pathway modulates immune dysregulation and associates with cardiovascular disease markers in SLE

2024-02-22

Abstract excerpt

What is already known on this topic Aconitate Decarboxylase 1 (ACOD1) is an enzyme involved in the synthesis of itaconate, a metabolite generated during the Krebs cycle. Itaconate has been identified as an immunomodulatory molecule ACOD1/Itaconate has been studied in the context of various inflammatory and autoimmune diseases, including sepsis, inflammatory bowel disease and rheumatoid arthritis. In these conditio...

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Literature Corpus work: 62baca3e-bd66-58d5-befc-5baba0be2a30
DOI: 10.1101/2024.02.20.24303097

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