Article

Differentiation and Expansion of Tumor-Infiltrating T Cell Clonotypes Occurs in the Spleen Following Immune Checkpoint Blockade

2023-09-06

Abstract excerpt

Immune checkpoint blockade (ICB) enhances tumor-reactive T cell responses against cancer, leading to long-term tumor control and survival in a fraction of patients. Given the increasingly recognized complexity of T cell differentiation that occurs in response to chronic antigen stimulation, it remains unclear precisely which T cell differentiation states are critical for the response to ICB, as well as the anatomi...

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Literature Corpus work: f81c03a0-fb03-5001-859a-fbc5cdb7a678
DOI: 10.1101/2023.09.04.555982

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Differentiation and Expansion of Tumor-Infiltrating T Cell Clonotypes Occurs in the Spleen Following Immune Checkpoint BlockadeDOI 10.1101/2023.09.04.555982Read

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