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Decreased cytotoxic T cells and TCR clonality in organ transplant recipients with squamous cell carcinoma

3 Jun 2020

Abstract excerpt

T-cell landscape differences between cutaneous squamous cell carcinoma (cSCC) tumors in immune competent (SCC in IC) and immunocompromised organ transplant recipients (TSCC in OTR) are unclear. We developed an analytical method to define tumor infiltrating lymphocyte (TIL) phenotype in cSCC from immune competent and immune suppressed patients using single-cell TCR sequencing and gene expression data. TSCC...

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PMID: 32550269
DOI: 10.1038/s41698-020-0119-9

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