Article

Disruption of CaMKII biomolecular condensation induces attention-deficit/hyperactivity disorder-like phenotypes

2026-06-29

Abstract excerpt

CaMKII is a multifunctional kinase essential for synaptic plasticity and memory formation. While its canonical role involves enzymatic phosphorylation, recent evidence suggests CaMKII also functions through liquid–liquid phase separation (LLPS) with substrate proteins, including GluN2B-containing NMDA receptors. However, the physiological significance remains unclear. Here, we generated CaMKII α subtype knock-in (...

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Literature Corpus work: 26e004a1-55a4-5bdd-b47a-75e13bb3f562
DOI: 10.64898/2026.06.24.734155

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