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Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation (LLPS) and its reversal by selective, potent and orally-available PDE11A4 small molecule inhibitors both <i>in vitro</i> and <i>in vivo</i>

2025-05-21

Abstract excerpt

<h4>ABSTRACT</h4> PDE11A is a little-studied phosphodiesterase family that breaks down cAMP and cGMP, with the PDE11A4 isoform enriched in the memory-related hippocampus. Age-related increases in hippocampal PDE11A expression occur in human and rodents, causing age-related cognitive decline of social memories. Interestingly, this age-related increase triggers PDE11A4 liquid-liquid phase separation (LLPS), causing...

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Literature Corpus work
12026fad-f68a-55d7-a6fe-4a55244e1568
DOI
10.1101/2025.05.20.654583
Open publication

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