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Article

The Pin1-CaMKII-AMPA Receptor Axis Regulates Epileptic Susceptibility.

Cerebral cortex (New York, N.Y. : 1991) - 10 May 2021

Hou Xiaojun, Yang Fan, Li Angcheng, Zhao Debao, Ma Nengjun, Chen Linying, Lin Suijin, Lin Yuanxiang, Wang Long, Yan Xingxue, Zheng Min, Lee Tae Ho, Zhou Xiao Zhen, Lu Kun Ping, Liu Hekun

Abstract excerpt

Pin1 is a unique isomerase that regulates protein conformation and function after phosphorylation. Pin1 aberration contributes to some neurological diseases, notably Alzheimer's disease, but its role in epilepsy is not fully understood. We found that Pin1-deficient mice had significantly increased seizure susceptibility in multiple chemical inducing models and developed age-dependent spontaneous epilepsy....

Topics

Animals
Brain
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Epilepsy
Genetic Predisposition to Disease
Humans
Male
Mice
Mice, Knockout
NIMA-Interacting Peptidylprolyl Isomerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pilocarpine

Receptors, AMPA

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 33569579
DOI: 10.1093/cercor/bhab004
PMCID: PMC8107790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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