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Article

Widely Used CaMKII Regulatory Segment Mutations Cause Tight Actinin Binding and Dendritic Spine Enlargement in Unstimulated Neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Dec 2025

Curtis Ashton J, Zhu Jian, Studniarczyk Dorota, Church Timothy W, Farrant Mark, Gold Matthew G

Abstract excerpt

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is essential for long-term potentiation (LTP) of excitatory synapses, a process fundamental to learning. CaMKII responds to Ca2+ influx into postsynaptic spines by phosphorylating proteins and forming new protein interactions. The relative importance of these enzymatic and structural functions is debated. LTP induction triggers CaMKII docking to NMDA receptors,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41130800
DOI: 10.1523/JNEUROSCI.0795-25.2025
PMCID: PMC12677114

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