Article

SynGAP regulates synaptic plasticity and cognition independent of its catalytic activity

2023-08-06

Abstract excerpt

SynGAP is an abundant synaptic GTPase-activating protein (GAP) critical for synaptic plasticity, learning, memory, and cognition. Mutations in SYNGAP1 in humans result in intellectual disability, autistic-like behaviors, and epilepsy. Heterozygous Syngap1 knockout mice display deficits in synaptic plasticity, learning, and memory, and exhibit seizures. It is unclear whether SynGAP imparts structural properties a...

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Literature Corpus work: 54e74ab3-4b5a-5b21-9b8c-19bb9c796f40
DOI: 10.1101/2023.08.06.552111

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