Article

The CDKL5 kinase undergoes liquid-liquid phase separation driven by a serine-rich C-terminal region and impaired by neurodevelopmental disease-related truncations

2024-11-18

Abstract excerpt

<h4>ABSTRACT</h4> Mutations of the cyclin-dependent kinase-like 5 (CDKL5) gene, which encodes a serine/threonine protein kinase, can cause the CDKL5 deficiency disorder (CDD), a severe neurodevelopmental disease characterized by epileptic encephalopathy and neurocognitive impairment. The CDKL5 kinase consists of a catalytic N-terminal domain (NTD) and a less characterized C-terminal domain (CTD). Numerous disea...

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Literature Corpus work: b79d116c-97cd-5dc2-a3d6-d6ebf1f5eeda
DOI: 10.1101/2024.11.18.624084

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