Article

T-cell Multiomic Analysis Identifies Subsets and Mechanisms of Interaction with Epithelial Cells in Idiopathic Pulmonary Fibrosis

2025-11-19

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive scarring and respiratory failure, with a median survival of 3–5 years. While T-cell numbers are elevated in IPF lungs, their contributions to fibrosis beyond inflammation remain poorly understood. Here, we performed multiplex imaging and single-cell RNA and protein profiling on ∼90,000 CD3⁺ T-cells from control an...

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Literature Corpus work: 4dca3d13-c20d-5064-98e8-1d566e6cd2f0
DOI: 10.1101/2025.11.19.689037

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