Article

Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis

2024-05-23

Abstract excerpt

Fibrosis drives end-organ damage in many diseases. However, clinical trials targeting individual upstream activators of fibroblasts, such as TGFβ, have largely failed. Here, we target the leukemia inhibitory factor receptor (LIFR) as a “master amplifier” of multiple upstream activators of lung fibroblasts. In idiopathic pulmonary fibrosis (IPF), the most common fibrotic lung disease, we found that lung myofibrobla...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c338827d-bbd2-57e9-90f7-b3b493782e17
DOI: 10.1101/2024.05.21.595153

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosisDOI 10.1101/2024.05.21.595153Read

T-cell Multiomic Analysis Identifies Subsets and Mechanisms of Interaction with Epithelial Cells in Idiopathic Pulmonary FibrosisSemantic proximity Read

Mechanisms and Therapeutic Potential of Myofibroblast Transformation in Pulmonary FibrosisSemantic proximity Read

Profibrotic priming of airway cell types and drug responses in early-stage idiopathic pulmonary fibrosisSemantic proximity Read

Sfrp1 inhibits lung fibroblast invasion during transition to injury-induced myofibroblastsSemantic proximity Read

Role of Fibroblast Growth Factor 10 in Mesenchymal Cell Differentiation During Lung Development and DiseaseSemantic proximity Read

Molecular mechanisms of pulmonary fibrosisSemantic proximity Read

Cellular and molecular mechanisms in fibrosisSemantic proximity Read

RNA-sequencing comparison of pneumonectomy and bleomycin reveals anti-fibrotic mechanisms of lung fibroblastsSemantic proximity Read

ACKR1-expressing venous endothelial cells establish a pro-fibrotic niche in pulmonary fibrosisSemantic proximity Read

Hyper-responsiveness of IPF/UIP fibroblasts: interplay between TGFbeta1, IL-13 and CCL2.Semantic proximity Read

Tracing the origin of pathologic pulmonary fibroblastsSemantic proximity Read

IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosisSemantic proximity Read