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Article

Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm.

Development (Cambridge, England) - 1 Jul 2007

Que Jianwen, Okubo Tadashi, Goldenring James R, Nam Ki-Taek, Kurotani Reiko, Morrisey Edward E, Taranova Olena, Pevny Larysa H, Hogan Brigid L M

Abstract excerpt

Sox2 is expressed in developing foregut endoderm, with highest levels in the future esophagus and anterior stomach. By contrast, Nkx2.1 (Titf1) is expressed ventrally, in the future trachea. In humans, heterozygosity for SOX2 is associated with anopthalmia-esophageal-genital syndrome (OMIM 600992), a condition including esophageal atresia (EA) and tracheoesophageal fistula (TEF), in which the trachea and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fibroblast Growth Factor 10

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Source

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Identifiers

PMID: 17522155
DOI: 10.1242/dev.003855
PMCID: PMC3625644

Genes

TEF
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm.PMID 17522155Read ↗

Multiple roles for Sox2 in the developing and adult mouse trachea.Semantic proximity Read ↗

Directed differentiation of EA/TEF patient-derived induced pluripotent stem cells into esophageal epithelial organoids reveal SOX2 dysregulation at the anterior foregut stageSemantic proximity Read ↗

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Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog/Gli Is Required for Tracheoesophageal SeparationSemantic proximity Read ↗

Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos.Semantic proximity Read ↗

Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation.Semantic proximity Read ↗

Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endodermSemantic proximity Read ↗

Mutations in SOX2 cause anophthalmia-esophageal-genital (AEG) syndromeSemantic proximity Read ↗

Disruption of a Hedgehog-Foxf1-Rspo2 Signaling Axis Leads to Tracheomalacia and a Loss of Sox9+ Tracheal ChondrocytesSemantic proximity Read ↗

Developmental basis of trachea-esophageal birth defectsSemantic proximity Read ↗

TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting multiple endogenous signaling pathwaysSemantic proximity Read ↗

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