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An organoid and multi-organ developmental cell atlas reveals multilineage fate specification in the human intestine

2020-07-25

Abstract excerpt

Human intestinal organoids (HIOs) generated from pluripotent stem cells provide extraordinary opportunities to explore development and disease. Here, we generate a single-cell transcriptome reference atlas from HIOs and from multiple developing human organs to quantify the specificity of HIO cell fate acquisition, and to explore alternative fates. We identify epithelium-mesenchyme interactions, transcriptional reg...

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Literature Corpus work
0eeb6449-0a69-505e-98c2-3ecd58b21c92
DOI
10.1101/2020.07.24.219147
Open publication

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An organoid and multi-organ developmental cell atlas reveals multilineage fate specification in the human intestineDOI 10.1101/2020.07.24.219147
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